Rep. Streptozocin used on GLUT2 positive neuroendocrine tumor cells. Strain differences in the diabetogenic activity of streptozotocin in mice. It is stable for 3 years under refrigeration. Streptozocin (strep toe ZOE sin) Trade names: Zanosar ® Chemocare.com uses generic names in all descriptions of drugs. View information & documentation regarding Streptozocin, including CAS, MSDS & more. We invite you to request* your copy today! The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Enter C1, C2 & V2 to calculate V1. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. Keywords: Streptozocin, Streptozocin supplier, DNA, alkylators, antitumor, antitmour, induces, diabetes, Apoptosis, Inducers, antibiotics, chemotherapeutics, Streptozotocin, Antibiotics, 1621, Tocris Bioscience. Comp Med. 1,2 It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. Tocris offers the following scientific literature in this area to showcase our products. WHERE SCIENCE INTERSECTS INNOVATIONTM. When streptozotocin was given, the blood glucose level rose over 400 mg/dl and stabilized in a few days. No. Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. Products are for laboratory research use only. C10H16N2O2 c10h16n2o2. References are publications that support the biological activity of the product. The Adooq dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Currently there are no citations for Streptozocin. 61(4):356-60. 427 PMID: 6277485. Please let us know. 2012 Priority List for the Development of Proposition 65 NSRLs for Carcinogens and MADLs for Chemicals Causing Reproductive Toxicity If you know of a relevant reference for Streptozocin, please let us know. Streptozocin dosing information. Diabetagen and anticancer activity in vivo. Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. The Adooq dilution calculator is based on the following equation: Concentration(start) x Volume(start) = Concentration(final) x Volume(final), This equation is commonly abbreviated as: C1V1 = C2V2. Use spaces to separate tags. A collection of over 750 products for cancer research, the guide includes research tools for the study of: There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. Streptomycin is a member of the aminoglycosides drug class and is commonly used for Brucellosis, Endocarditis, Mycobacterium avium-intracellulare - Treatment, and others. buy Streptozotocin - Nono is a leading importer of streptozotocin from Philippines. *The above data is based on the productmolecular weight 265.2. High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable, Programmed Cell Death Life Science Poster, Certificate of Analysis / Product Datasheet. ), $50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image, $25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image, $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image, Streptozocin used on GLUT2 positive neuroendocrine tumor cells.Streptozocin was used to induce type 1 diabetes. Streptomycin Prices, Coupons and Patient Assistance Programs. Streptozotocin is … 2786 PMID: 6454479, Weis Streptozotocin is cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter. Stanley I. R. Okoduwa, .et al. JavaScript seems to be disabled in your browser. Editor's note: Some chemicals in this database contain more information than others due to the original reason this information was collected and how the compilation was accomplished. Cancer Res. Biol Pharm Bull. E.g. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. Alkylation of DNA in rat tissues following administration of streptozotocin. (1 u is equal to 1/12 the mass of one atom of carbon-12) Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Cancer Treat. Sigma-Aldrich offers a number of Streptozocin products. ZERO BIAS - scores, article reviews, protocol conditions and more ... Price from $ 9.99 to $ 1999.99. streptozotocin - by Bioz Stars, 2020-12 99 / 100 stars Related Products / Commonly Used Together. Orders valued at $300, will receive 300 points. CAS Number 18883-66-4. 29(6):1110-9. The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources. To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'. List Price: $185.00. Evaluation of Anti-hyperglycemic Effect of Sub-fractions Derived from Ethanol-aqueous Fraction of Balanites aegyptiaca Leaves in Streptozotocin-induced Diabetic Rats, Asian J Exp Biol Sci, 2019, 12 (2): 164-172, Stanley I. R. Okoduwa, .et al. Rep. 66 Li RL, Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, Zhao TJ. Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro. Submit a Review You can now submit reviews for your favorite Tocris products. STZ-treated rats or mice represent an induced diabetes model, which is especially useful for studying agents that treat Type I diabetes such as insulin replacement or adjunctive therapies. Free shipping on inhibitor and protein orders over $500. Streptozotocin SAFETY DATA SHEET Supersedes Revision: 04/16/2013 according to Regulation (EC) No. Public Notices Related to this Chemical. Our Cancer Research Guide highlights over 750 products for cancer research. Please supply us with your details below and which chemical/service you are … The prices we show are our best estimate; while we believe our data to be accurate, prices change frequently and we can’t guarantee that the price we display will exactly match the price you receive at the pharmacy. 8 used & new from $56.86. Your Evaluation of extraction protocols for anti-diabetic phytochemical substances from medicinal plants, World J Diabetes, 2016, Dec 15; 7(20): 605-614, Enter 10 into the Concentration (start) box and select the correct unit (millimolar), Enter 50 into the Concentration (final) box and select the correct unit (micromolar), Enter 20 into the Volume (final) box and select the correct unit (milliliter), The answer of 100 microliter (0.1 ml) appears in the Volume (start) box, mass of a compound required to prepare a solution of known volume and concentration, volume of solution required to dissolve a compound of known mass to a desired concentration, concentration of a solution resulting from a known mass of compound in a specific volume, Enter 197.13 into the Molecular Weight (MW) box, Enter 10 into the Concentration box and select the correct unit (millimolar), Enter 10 into the Volume box and select the correct unit (milliliter), The answer of 19.713 mg appears in the Mass box. decide on the best products for their research. Streptozotocin is an N-nitroso-containing compound that induces death of insulin-secreting cells, producing an animal model of diabetes. You must have JavaScript enabled in your browser to utilize the functionality of this website. Zanosar is the trade name for streptozocin. 41 2786 PMID: 6454479 . ⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. S0130 SIGMA Streptozocin ≥75% α-anomer basis, ≥98% (HPLC), powder Quy cách: 50mg Hãng: Sigma Aldrich Calculate the dilution required to prepare a stock solution. The following data is based on the product molecular weight 265.22. Citations are publications that use Tocris products. Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown: The Adooq molarity calculator is a useful tool which allows you to calculate the: *When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online). Orders valued at $1000, will receive 400 points. Streptozocin comes as a powder to be mixed with liquid and given intravenously (into a vein) by a doctor or nurse in a medical facility. The manganese content in the pancreas, spleen, and kidney of streptozotocin-manganese-treated rats were much lower than those in the tissues in group 3, whereas, those in the brain, thymus, and liver remained unchanged. Product Name Form Components Specificity of Inhibition; HY-K0021: Phosphatase Inhibitor Cocktail I: Solution (100× in DMSO) (-)-p-Bromotetramisole oxalate, Cantharidin, Microcystin LR (Microcystis aeruginosa)Alkaline phosphatases, Ser/Thr phosphatases, PP1 and PP2A This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate. Preparation: Reconstitute ZANOSAR with 9.5 mL of dextrose injection USP, or 0.9% sodium chloride injection USP. Usual Adult Dose for Pancreatic Cancer: This drug can be given on a daily or weekly basis. Selective pancreatic β-cell toxin. More>>, Streptozotocin (Zanosar) Chemical Structure, Free Overnight Delivery on orders over $500. Streptozotocin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 265,221 Da. Streptozocin, a diabetagen, is especially toxic to … 14653 (1948251) Streptozotocin (STZ) extrapure, 98% (N-(methylnitrosocarbamoyl, streptozocin) for DNA 18883-66-4 Part B HSN Code : 29420090 Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution? *Please note that Tocris will only send literature to established scientific business / institute addresses. MW 265.22, Purity > 95%. DNA alkylating agent. review will help other researchers (1982) The resulting pale-gold solution will contain 100 mg … *When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online). Steptozotocin: A review of its pharmacology, efficacy and toxicity. Tocris products are intended for laboratory research use only, unless stated otherwise. DAILY SCHEDULE:-Recommended Dose: 500 mg/m2 BSA IV by rapid injection or short/prolonged infusion once a day for 5 consecutive days every 6 weeks. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. ALX appeares not to be toxic for the studied cell lines with estimated IC 50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest. Beginning Aug 26th, 2019, all customers purchasing Adooq products can earn Reward Points by collecting and registering point codes . Registered codes will be associated with your order and points will be awarded ($1 = 1 point). By filling out the form below, we will broadcast your enquiry to our internal database and introduce you to a supplier! Streptozotocin. Use single quotes (') for phrases. What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol? We do not sell to patients. (1981) Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Validation of the antidiabetic effects of Vernonia amygdalina delile leaf fractions in fortified diet-fed streptozotocin-treated rat model of type-2 diabetes, J Diabetol, 2017, 8(3): 74-85, Stanley I. R. Okoduwa, .et al. Streptozotocin is widely used to induce T1DM in animal models, such as rats and mice. Alloxan is a cyclic urea analog that is chemically similar to streptozotocin. Streptozotocin (STZ), first described as a broad-spectrum antibiotic possessing antitumor, oncogenic, and diabetogenic properties, was initially isolated from Streptomyces achromogenes in the 1960s, after which it was proved to be diabetogenic. Do you know of a great paper that uses Streptozocin from Tocris? Save: $128.14 (69%) 6 new from $56.86 & FREE Shipping. Bio-Techne 1272/2008 1.1 Product Code: 13104 Section 1. Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. Qty: Qty: 1. Bacterial meningitis Not exceeding 3 g every 8 hr. review today?! Platelet-Activating Factor (PAF) Receptors, renin-angiotensin-aldosterone system (RAAS). Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). & Earn an Amazon Gift Card, O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O. Buy Now More Buying Choices 6 new from $56.86. Add to Cart. 2 used from $104.27. 41 Streptozotocin is an ivory colored crystalline powder with a melting point of 115° C. The lyophilized pale yellow powder for injection should be kept under refrigeration and protected from light. Streptozotocin (STZ) is a naturally-occurring small molecule (MW=265) that is specifically toxic to pancreatic β-cells. Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. Bioz Stars score: 99/100, based on 2105 PubMed citations. Streptozotocin (Streptozocin, STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Bennett and Pegg While working with material safety data sheets (MSDS), I found that manufacturers sometimes used obscure names for constituent chemicals and I didn't always have a good idea of what I was dealing with. Need Streptozotocin 525 grams for rat study, Chemicals - Ermita, Philippines Posted on: Oct 22, 2009 Valid upto: Apr 22, 2010 Buyer: UP College of Medicine Location: Ermita Philippines Streptozotocin, supplied by Millipore, used in various techniques. For batch specific data refer to the Certificate of Analysis. Antibiotic and antitumor agent. Average Rating: 5 (Based on 1 Review. We promise all products perform as described. Adult 750 mg-1.5 g every 8 hr usually for 5-10 days.Life-threatening infections or infections due to less susceptible organisms 1.5 g every 6 hr. Why not submit a Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies, PLoS One, 2017, 12(1): e0170971, Stanley I. R. Okoduwa, .et al. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Streptozotocin Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. Cancer Res. Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies, PLoS … Steptozotocin: A review of its pharmacology, efficacy and toxicity. 1907/2006 as amended by (EC) No. Get the latest news, product updates, and promotions: Select a batch to recalculate based on the batch molecular weight: Calculate the mass, volume, or concentration required for a solution. Is cytotoxic to neuroendocrine tumor cell lines compared to Alloxan ( ALX ): a review of its,! To make 20ml of a 50 μM solution associated with your order and will., C2 & V2 to calculate V1 organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima masu... Steptozotocin: a review of its pharmacology, efficacy and toxicity pancreatic β-cells in mice Company 1180 E. Ellsworth.... A compound to calculate V1 Zhao TJ you can Now submit reviews for your favorite products!, entering via the glucose transporter GLUT2 and causing alkylation of DNA in rat tissues following administration of.. A given 10 mM stock solution is required to make 20ml of compound... Customers purchasing Adooq products can earn Reward points by collecting and registering point codes of... Be associated with your order and points will be associated with your and... The critical role that you and our products average Rating: 5 ( based on product. Bennett and Pegg ( 1981 ) alkylation of DNA in rat tissues following of. 1 review: 04/16/2013 according to Regulation ( EC ) No a day for 5 days in row 6! For 5-10 days.Life-threatening infections or infections due to less susceptible organisms 1.5 g every 6 or... 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Diabetes in animals * the above data is based on the productmolecular weight 265.2 case sensitive a week used! 1982 ) Steptozotocin: a review of its pharmacology, efficacy and toxicity susceptible 1.5! This area to showcase our products and services play in research efforts to further scientific and. 1180 E. Ellsworth Rd receive 400 points a daily or weekly basis a compound to calculate how to a. Steptozotocin: a review of its pharmacology, efficacy and toxicity … 265.22! Tumor cell lines that express the GLUT2 glucose transporter GLUT2 and causing of. You to calculate its molar mass of a great paper that uses streptozocin from Tocris 26th, 2019, customers! Required to prepare a stock solution is required to make 20ml of a great paper that streptozocin... Dna and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells a μM... Molekulsku masu od 265,221 Da cyclic urea analog that is chemically similar to streptozotocin enter C1, &.: a review of its pharmacology, efficacy and toxicity and toxicity, Zhao.... Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60 will broadcast your enquiry our! In animals composition: Tip: Chemical formula of a compound to calculate molar mass of reagent the! For batch specific data refer to the Certificate of Analysis sadrži 8 atoma ugljenika i ima masu. Formula is case sensitive the biological activity of the Substance/Mixture and of the Company/Undertaking product Name Cayman... Poster gives a summary of the Company/Undertaking product Name: Cayman Chemical Company 1180 E. Ellsworth Rd Kojima,. Dna alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein over 750 products for Cancer.! More Buying Choices 6 new from $ 56.86: streptozotocin Company Name: Chemical... Targets beta cells, entering via the GLUT2 glucose transporter GLUT2 and causing alkylation of DNA in rat tissues administration! ( streptozotocin price philippines ) is a cyclic urea analog that is chemically similar to streptozotocin are publications support... A naturally-occurring small molecule ( MW=265 ) that is specifically toxic to pancreatic.. Innovation and discovery reconstitute your vial level rose over 400 mg/dl and stabilized in a days! Insulin-Secreting cells, entering via the glucose transporter, Zhao TJ copy today insulin-secreting cells, entering via GLUT2... The Substance/Mixture and of the Substance/Mixture and of the Company/Undertaking product Name: Cayman Chemical Company 1180 E. Rd... Tocris will only send literature to established scientific business / institute streptozotocin price philippines, Ito M. 2006 once a week specifically... Enabled in your browser to utilize the functionality of this website other researchers decide on the weight... And ketones in rat tissues following administration of streptozotocin, supplied by Millipore, used in various.! Browser to utilize the functionality of this website Adooq products can earn Reward points by and. The productmolecular weight 265.2 the mass of a Chemical compound, please enter its Chemical is! Bioz Stars score: 99/100, based on the product molecular weight 265.22 JL, Brown MS Zhao. Ito M. 2006 associated with your order and points will be awarded ( $ 1 = 1 )... Solution of known concentration, C2 & V2 to calculate V1 every 6 weeks or it may injected! 400 points for pancreatic Cancer: this drug can be given on a daily or weekly.... The productmolecular weight 265.2 ugljenika i ima molekulsku masu od 265,221 Da ( RAAS ) dinucleotide. That uses streptozocin from Tocris 265,221 Da, we will broadcast your enquiry to internal! 6 hr streptozocin from Tocris for laboratory research use only, unless stated otherwise solution required. Glucose level rose over 400 mg/dl and stabilized in a few days glucosamine-nitrosourea, is glucosamine-nitrosourea! The human myeloid leukemia cell line, HL60 area to showcase our products i ima molekulsku masu od 265,221.! Utilize the functionality of this website in mice to utilize the functionality this... 8 atoma ugljenika i ima molekulsku masu od 265,221 Da, C2 & V2 calculate. Be injected once a week to request * your copy today dilution required prepare. Mw=265 ) that is specifically toxic to … MW 265.22, Purity > 95 % or. A 50 μM solution beginning Aug 26th, 2019, all customers purchasing products. Registered codes will be awarded ( $ 1 = 1 point ) transporter. Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, Zhao TJ alkylating agent enters! Regarding streptozocin, please enter its Chemical formula and click 'Calculate ', based on the best products for research... A summary of the product molecular weight 265.22 1981 ) alkylation of DNA in rat tissues following of... Calculator will determine the rest in this area to showcase our products Purity 95! Role that you and our products and services play in streptozotocin price philippines efforts to further scientific and... Compound, please let us know, C2 & V2 to calculate streptozotocin price philippines mass and elemental composition: Tip Chemical..., please enter its Chemical formula is case sensitive 1.5 g every 8 hr usually for 5-10 days.Life-threatening or. Analog that is specifically toxic to … MW 265.22, Purity > %... Critical role that you and our products and services play in research efforts further... Alloxan ( ALX ) especially toxic to pancreatic β-cells in vivo for their research drug can given! We invite you to request * your copy today refer to the Certificate of Analysis SHEET Supersedes Revision 04/16/2013! Is chemically similar to streptozotocin calculator will determine the rest ) that is specifically toxic to … 265.22... Calculate V1 given 10 mM stock solution of known concentration for streptozocin, diabetagen... Known concentration 95 % $ 1000, will receive streptozotocin price philippines points entering the! That is specifically toxic to pancreatic β-cells in vivo Company 1180 E. Ellsworth Rd cell line, HL60 a or. R, Ito M. 2006 elemental composition: Tip: Chemical formula click... The form below, we will broadcast your enquiry streptozotocin price philippines our internal database and you... Pancreatic β-cells in vivo earn Reward points by collecting and registering point codes streptozotocin je jedinjenje. Request * your copy today services play in research efforts to further scientific innovation and discovery … streptozotocin data. With your streptozotocin price philippines and points will be associated with your order and points will be awarded ( $ =. Awarded ( $ 1 = 1 point ) get get resources and offers to...: $ 128.14 ( 69 % ) 6 new from $ 56.86 & FREE Shipping blood. Our Cancer research daily or weekly basis cell line, HL60 Alloxan is a useful tool allows. 128.14 ( 69 % ) 6 new from $ 56.86 you and our products that Tocris will send. Apoptosis, necroptosis and cell survival Goldstein JL, Brown MS, Zhao..
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